Accutane (isotretinoin) has a long history of controversy over birth defects, depression and suicide, and other serious medical problems. UKPAR Isotretinoin 40mg Soft Capsules PL 04569/0723 2 ISOTRETINOIN 40MG SOFT CAPSULES (PL 04569/0723) LAY SUMMARY The MHRA today granted Generics (UK) Limited a Marketing Authorisation Compare prices, print coupons and get savings tips for Isotretinoin and other Acne drugs at CVS, Walgreens, and other pharmacies. Prices start at $196.20 Find patient medical information for Isotretinoin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Isotretinoin reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Oral isotretinoin (13-cis retinoic acid) is a retinoid most often used for the treatment of acne vulgaris, particularly severe or recalcitrant disease. Isotretinoin is teratogenic and associated with a number of other adverse effects that can limit its use. Thus, it must be used with caution and Isotretinoin is available in a variety of brand names, including Absorica, Amnesteem, Claravis, Myorisan, and Sotret. The original brand, Accutane, is no longer on the market. Isotretinoin (Accutane) is a medication that is used to treat severe recalcitrant nodular acne when nothing else seems to work. Teens who take isotretinoin have severe acne and typically have tried many other acne treatments, including oral antibiotics and multiple topical medications. Special Prescribing Requirements. Because of Accutane (isotretinoin) 's teratogenicity and to minimize fetal exposure, Accutane (isotretinoin) is approved for marketing only under a special restricted distribution program approved by the Food and Drug Administration. Myorisan (isotretinoin capsules, USP), compare to CLARAVIS : Akorn - Sterile Ophthalmics and Injectables.